Large global patient study confirms circulating tumor DNA feasible for EGFR mutation analysis

EGFR mutation testing of tumor sample DNA from patients with nonsquamous advanced NSCLC is advocated by clinical guidelines (1, 2) and working groups (3, 4) and is required to confirm whether patients should receive EGFR tyrosine kinase inhibitor (TKI) treatment. However, tissue samples are not always available or evaluable for diagnosis and mutation testing, leaving… Read article →


Pyrosequencing for MGMT promoter methylation analysis validated for use in clinical practice

Pyrosequencing is reported as the ideal method for MGMT methylation analysis, and is validated for use in clinical practice. Methylation of the O6-methylguanine- DNA-methyltranferase (MGMT) promoter region is associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. MGMT promoter methylation is a powerful predictive biomarker of positive response to temozolomide, a… Read article →


Leading Innovation in Biomarker Testing: Next-Generation Sequencing (NGS)

Cutting edge approaches such as NGS are the future of biomarker testing, but require expertise from industry leaders like QIAGEN to develop. QIAGEN’s biomarker assays are designed to ease the challenges faced by those who perform the tests. By engaging with stakeholders, such as laboratorians and oncologists, QIAGEN’s diagnostic assays aim to deliver multiple benefits… Read article →


QIAGEN launches unique CALR mutation assay for MPN diagnosis

European launch of the new CE marked ipsogen CALR RGQ PCR Kit to improve MPN diagnosis for leukemia patients in line with latest WHO recommendations and clinical guidelines HILDEN, Germany, Dec. 1, 2016 – QIAGEN today announced the European launch of a unique CE-IVD marked calreticulin (CALR) mutation assay to aid in establishing the diagnosis… Read article →


Leading Innovation in Biomarker Testing: Liquid Biopsy

Cutting edge approaches which use techniques such as liquid biopsy are the future of biomarker testing, but require expertise and leadership to develop. QIAGEN’s companion diagnostic assays are designed to ease the challenges faced by pathologists in labs performing the tests. By engaging with stakeholders, such as laboratorians and oncologists, QIAGEN’s diagnostic assays aim to… Read article →


QIAGEN GeneReader NGS System to relaunch in U.S. market

New improved chemistry for first Sample to Insight next-generation sequencing solution to be made available to first customers in December 2016 Charlotte, North Carolina, and Hilden, Germany, November 9, 2016 – QIAGEN N.V. (NASDAQ: QGEN; Frankfurt Prime Standard: QIA) today announced the validation of new and improved sequencing  chemistry for its GeneReader NGS System, the… Read article →


QIAGEN’s NGS solutions highlighted at the annual Congress of the European Society of Pathology

QIAGEN’s broad portfolio of Sample to Insight solutions for NGS were a focus at the QIAGEN booth and industry symposium at this year’s annual Congress of the European Society of Pathology. The XXXI International Congress of the International Academy of Pathology (IAP) and 28th Congress of the European Society of Pathology (ESP) was hosted for… Read article →


The Prognostic Significance of Gene Mutations in Myeloproliferative Neoplasms

Relevant gene mutations in MPN and their prognostic significance for primary myelofibrosis (PMF). Myeloproliferative neoplasms (MPN) are a group of blood cancers characterized by significant symptoms and a high risk of transformation into acute leukemia. MPN include (primary) myelofibrosis (PMF), essential thrombocythemia (ET) and polycythemia vera (PV), and affect around 13,000, 134,000 and 148,000 patients… Read article →



Large global patient study confirms circulating tumor DNA feasible for EGFR mutation analysis

EGFR mutation testing of tumor sample DNA from patients with nonsquamous advanced NSCLC is advocated by clinical guidelines (1, 2) and working groups (3, 4) and is required to confirm whether patients should receive EGFR tyrosine kinase inhibitor (TKI) treatment. However, tissue samples are not always available or evaluable for diagnosis and mutation testing, leaving… Read article →


QIAGEN at AMP 2016

Join us at AMP for solutions, from trusted molecular detection to clinical decision support The AMP 2016 Annual Meeting is just around the corner, and we’re excited to see you there at the Convention Center in Charlotte, NC, Nov 10—12! Stop by our booth! Come to booth #1119 to explore our products and speak with our… Read article →


WT1 expression and NPM1 mutations as biomarkers for minimal residual disease (MRD) monitoring in AML patients

The AML Global Portal highlights the value of AML biomarkers WT1 expression and NPM1 mutation for MRD monitoring in AML patients The AML_Global_Portal is an evidence-based online resource committed to informing and educating health care providers about the latest cutting-edge advancements in acute myeloid leukemia (AML). The portal aims to help advance understanding and share… Read article →


QIAGEN at ESMO 2016

Meet us there to discuss how our next-generation oncology solutions can take you from sample to insight! The ESMO_2016_Meeting is just around the corner, and we’re excited to see you there from Oct. 7 – 11 in Copenhagen! Here at QIAGEN, we are proud to be part of the collaborative effort to improve cancer care…. Read article →


Improved research and diagnostics could help reduce the economic burden of blood disorders

Since the arrival of personalized healthcare and molecular diagnostics, there has been growing support for utilizing DNA, RNA, and protein-based biomarker detection methods as a means to help reduce rising healthcare costs (1). Molecular diagnostics can help select the right patients for the right treatments, and define which patients require costly confirmatory diagnostic tests. In… Read article →


QIAGEN is at ECP 2016 in Cologne!

Meet us there to discuss the new NGS solution to cancer research – our Sample to Insight approach! This year the XXXI International Congress of the International Academy of Pathology (IAP) and the 28th Congress of the European Society of Pathology (ESP) is being hosted as a joint venture in Cologne from September 25–29 (see conference… Read article →


QIAGEN’s companion diagnostic business highlighted in the Journal of Precision Medicine

A recent publication in the Journal of Precision Medicine highlights QIAGEN’s companion diagnostic business development and Modaplex platform. The July 2016 issue of the Journal_of_Precision_Medicine (JPM) features an article by Jessica Johnson called “Companion Diagnostics – a Burgeoning Market” (1). In this article, Johnson provides a brief account of the recent history of companion diagnostics… Read article →


ESMO guidelines committee update clinical recommendations for metastatic colorectal cancer

The European Society for Medical Oncology (ESMO ) is a leading European professional organization for medical oncology and is considered the reference society for oncology education and information. Comprised of more than 13,000 oncology professionals from over 130 countries, ESMO is a home for all oncology stakeholders, and connects professionals with diverse expertise and experience…. Read article →


New study suggests RT-PCR-based ALK assay useful in clinical practice

Anaplastic lymphoma kinase (ALK) gene rearrangements are found in 3–5% of lung adenocarcinomas (ADC) (2–4, Figure 1), and over 20 ALK fusion partners have been implicated in non-small-cell lung cancer (NSCLC) (5). Thanks to the relatively recent development of small molecule targeted therapies, the ALK oncogene is now targetable using ALK tyrosine kinase inhibitors (TKIs)… Read article →


QIAGEN launches novel integrated system for collection, stabilization, transport, storage and isolation of circulating cell-free DNA

Hilden, Germany, and Germantown, Maryland, July 27, 2016 – QIAGEN N.V. (NASDAQ: QGEN; Frankfurt Prime Standard: QIA) today announced the launch of the new PAXgene® Blood ccfDNA Tube* for venous whole blood collection and room temperature stabilization of in-vivo circulating cell-free DNA (ccfDNA) profiles. Together with the QIAamp Circulating Nucleic Acid Kit – the gold… Read article →


Growing evidence that MET inhibition could treat NSCLC

Evidence continues to grow for the potential therapeutic benefit of mesenchymal-epithelial transition factor proto-oncogene (MET) inhibition to treat non-small cell lung cancer (NSCLC). A recent study by Tong et al. (1) published this past June on MET DNA alterations in NSCLC provides further evidence of the critical role of aberrant MET signaling in the pathogenesis… Read article →


WHO Releases Updated Guidelines for Classification of Myeloid Neoplasms and Acute Leukemia

The right diagnosis can lead to the right treatment: Recent advances in the identification of unique biomarkers associated with some myeloid neoplasms and acute leukemia have prompted the World Health Organization (WHO) to update its 2008 Classification of Tumors of Hematopoietic Tissues (1). These revised guidelines were recently published in Blood. This new 2016 classification does… Read article →


QIAGEN forms Lung Cancer Expert Alliance

Hilden, Germany, and Germantown, Maryland, June 2, 2016 – QIAGEN N.V. (NASDAQ: QGEN; Frankfurt Prime Standard: QIA) today announced the formation of a global consortium of international lung cancer experts who will advise the company on the design of new next-generation sequencing (NGS) gene panels and associated workflows that target lung cancer-specific mutations. The members… Read article →


QIAGEN launches liquid biopsy workflow for GeneReader NGS System

  Actionable Insights Tumor Panel enables monitoring of cancer biomarkers from plasma samples Hilden, Germany, and Germantown, Maryland, June 1, 2016 – QIAGEN N.V. (NASDAQ: QGEN; Frankfurt Prime Standard: QIA) today announced the launch of its liquid biopsy workflow for clinical cancer research using QIAGEN’s GeneReader NGS System for next-generation sequencing (NGS). The Actionable Insights… Read article →


QIAGEN partners to develop predictive tests in oncology

Yesterday, we announced that QIAGEN was entering into a licensing and co-development agreement with Therawis Diagnostics GmbH to develop and commercialize predictive assays in oncology. An initial project will be to develop and market PITX2 as a marker to predict effectiveness of anthracycline treatment in triple negative and other high-risk breast cancer patients. See the full press release… Read article →


Infographic: Filtering the flood

The global DNA sequencing capacity is increasing 3x-5x per year, leading to an unprecedented flood of biological data. Already, the output of biological data amounts to 15 petabytes a year (the equivalent of >3 million DVDs) and its amount doubles every 9 months, making it hard for scientists to keep up and put the information… Read article →