Next generation sequencing (NGS) holds much promise for the research and diagnosis of complex genetic diseases like cancers. The massively parallel sequencing makes it possible to detect somatic and germline mutations – even though these typically present at only a low level. Here, in Part 2 of this article, we continue to describe the role...
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Myeloid malignancies are complex clonal diseases arising in hematopoietic stem or progenitor cells. These heterogenous disorders comprise many different subtypes such as myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS), myelodysplastic/myeloproliferative neoplasms (MDS/MPN) and acute myeloid leukemia (AML). There is a growing need for molecular profiling of these blood and bone marrow disorders to provide better definition...
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